abstract：:In yeast, 17 histidine-requiring mutants derived from and interallelically complementary to his1-7 were analyzed. The genetic basis of the complementation response was elucidated by mitotic and meiotic gene conversion. Each allele probably carries an unaltered 7-site mutation and a unique second-site alteration. The s...

journal_title：Genetics

authors： Lax C,Fogel S

更新日期：1978-11-01 00:00:00

abstract：:To inquire whether the loci identified by recombination-defective and disjunction-defective meiotic mutants in Drosophila are also utilized during mitotic cell division, the effects of 18 meiotic mutants (representing 13 loci) on mitotic chromosome stability have been examined genetically. To do this, meiotic-mutant-b...

journal_title：Genetics

authors： Baker BS,Carpenter AT,Ripoll P

更新日期：1978-11-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:Strains of Dictyostelium discoideum resistant to cobaltous chloride have been isolated at a frequency of approximately 10(-6). The resistant strains have one of three phenotypes, recessive to wild type, dominant to wild type and dominant to wild type but requiring the presence of cobaltous chloride to maintain resista...

journal_title：Genetics

authors： Williams KL

更新日期：1978-09-01 00:00:00

abstract：:Data are presented concerning the gene arrangements in both arms of the X-chromosome of Drosophila robusta in eight altitudinal transects. The major change appears to be the increase of gene arrangement XL-1 (and decrease in XL, sometimes also XL-2) with increasing altitude. In each transect only one combination of XL...

journal_title：Genetics

authors： Levitan M

更新日期：1978-08-01 00:00:00

abstract：:The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...

journal_title：Genetics

authors： Hedrick PW

更新日期：1978-06-01 00:00:00

abstract：:This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1(-) mutants induced within them. Twenty-two biochemically characterized Adh1(-) mutants have been assessed for ability to recombine intragenically, using data generated by specifically staini...

journal_title：Genetics

authors： Freeling M

更新日期：1978-05-01 00:00:00

abstract：:A spontaneously arising nuclear mutation, ss-1, has been identified in Chlamydomonas reinhardtii that decreases both streptomycin and spectinomycin resistance levels about 10-fold after its introduction into all wild-type, streptomycin-resistant and spectinomycin-resistant strains examined. The mutations for resistanc...

journal_title：Genetics

authors： Lee RW,Sapp JA

更新日期：1978-04-01 00:00:00

abstract：:The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that ...

journal_title：Genetics

authors： Nagylaki T

更新日期：1978-04-01 00:00:00

abstract：:Allozyme and inversion data from natural populations of Drosophila melanogaster from the eastern United States were analyzed to determine whether the clines at allozyme loci are due to nonrandom associations with common cosmopolitan inversions. All inversions show strong clines. Clines were large and significant for h...

journal_title：Genetics

authors： Voelker RA,Cockerham CC,Johnson FM,Schaffer HE,Mukai T,Mettler LE

更新日期：1978-03-01 00:00:00

abstract：:The possibility that fitness relationships associated with an inversion polymorphism in D. paulistorum were frequency dependent was investigated. Using allozymes of tetrazolium oxidase to mark inversions, the effects of genotype frequency, larval density, and culture conditions on fitness were assessed. The proportion...

journal_title：Genetics

authors： Gromko MH,Richmond RC

更新日期：1978-02-01 00:00:00

abstract：:By using both numerical and analytical approaches, we have shown that heterosis alone is not a mechanism for maintaining many alleles segregating at a locus. Even when all heterozygous are more fit than all homozygotes, the proportion of fitness arrays that will lead to a stable, feasible equilibrium of more than 6 or...

journal_title：Genetics

authors： Lewontin RC,Ginzburg LR,Tuljapurkar SD

更新日期：1978-01-01 00:00:00

abstract：:The results of deficiency mapping experiments reveal the presence of a compensatory response (cr+) locus that is located distal to the cluster of ribosomal RNA (rRNA) genes and is responsible for disproportionately replicating these genes when cr+ locus is present in a single dose, as in X/O males or X/sc4-sc8 females...

journal_title：Genetics

authors： Procunier JD,Tartof KD

更新日期：1978-01-01 00:00:00

abstract：:Drosophila melanogaster X chromosomes were mutagenized by feeding males sucrose solutions containing ethyl methanesulfonate (EMS); the concentrations of EMS in the food were 2.5 mM, 5.0 mM, and 10.0 mM. Chromosomes were exposed to the mutagen up to three times by treating males in succeeding generations. After treatme...

journal_title：Genetics

authors： Mitchell JA

更新日期：1977-12-01 00:00:00

abstract：:Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determin...

journal_title：Genetics

authors： Koval TM,Hart RW,Myser WC,Hink WF

更新日期：1977-11-01 00:00:00

abstract：:Two closely related bacteriophage, varphiCr30 and varphiCr35, are the first bacteriophage shown to mediate generalized transduction in Caulobacter crescentus. Unlike most other transducing phage, they are virulent and do not form any sort of lysogenic relationship with their host. However, they are rather inefficient ...

journal_title：Genetics

authors： Ely B,Johnson RC

更新日期：1977-11-01 00:00:00

abstract：:An inbreeding matrix is defined for populations with overlapping generations. In the short term it can be expressed in terms of a matrix specifying the passage of genes between the different age groups (and sexes) and a diagonal matrix whose elements depend on the number of individuals in each age group. Formulae for ...

journal_title：Genetics

authors： Johnson DL

更新日期：1977-11-01 00:00:00

abstract：:Homothallic strains of Saccharomyes cerevisiae are able to switch efficiently from one mating genotype to another. From a single haploid spore arise both a and mating type cells, which then self-mate to produce a colony consisting almost exclusively of nonmating a/ diploid cells. We have isolated a mutant homothallic ...

journal_title：Genetics

authors： Haber JE,Garvik B

更新日期：1977-09-01 00:00:00

abstract：:A flight test box was developed and used in the isolation and initial characterization of Drosophila melanogaster mutants defective in flight behavior. Forty-eight mutants were isolated from F(1) progeny of ethyl methanesulfonate-treated males. Genetic mapping and complementation tests show that the mutations reside a...

journal_title：Genetics

authors： Homyk T,Sheppard DE

更新日期：1977-09-01 00:00:00

abstract：:This paper draws attention to the formal parallelism that exists between chromosomal-loss mosaicism and mutagenically induced mosaicism in Drosophila and suggests that, although the underlying processes by which these two types of genetic mosaics are generated are very different, the more refined methodology employed ...

journal_title：Genetics

authors： Nissani M

更新日期：1977-08-01 00:00:00

abstract：:Two independent isolates of Saccharomyces cerevisiae lacking hexokinase activity (EC 2.7.1.1) are described. Both mutant strains grow on glucose but are unable to grow on fructose, and contain two mutant genes hxk1 and hxk2 each. The mutations are recessive and noncomplementing. Genetic analysis suggests that these tw...

journal_title：Genetics

authors： Lobo Z,Maitra PK

更新日期：1977-08-01 00:00:00

abstract：:Properties of identity relation between genes are discussed, and a derivation of recurrent equations of identity coefficients in a random mating, diploid dioecious population is presented. Computations are run by repeated matrix multiplication. Results show that for effective population size (Ne) larger than 16 and no...

journal_title：Genetics

authors： Chevalet C,Gillois M,Nassar RF

更新日期：1977-07-01 00:00:00

abstract：:Lethal and sterility mutations were accumulated in a cage population which was initiated with lethal- and sterility-free second chromosomes of D. melanogaster. It took about 2,000 days for the frequencies of these genes to reach equilibrium levels, i.e., 18% lethal and 9% male-sterile chromosomes. Two other cage popul...

journal_title：Genetics

authors： Lee WH,Watanabe TK

更新日期：1977-07-01 00:00:00

abstract：:Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...

journal_title：Genetics

authors： Hodgkin JA,Brenner S

更新日期：1977-06-01 00:00:00

abstract：:The experimental population genetics of Y-chromosome drive in Drosophila melanogaster is approximated by studying the behavior of T(Y;2),SD lines. These exhibit "pseudo-Y" drive through the effective coupling of the Y chromosome to the second chromosome meiotic drive locus, Segregation distorter (SD). T(Y;2),SD males ...

journal_title：Genetics

authors： Lyttle TW

更新日期：1977-06-01 00:00:00

abstract：:The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a position occupied in the wild type by glutamate. Two classes of am(17) revertants due to further mutation within the am gene...

journal_title：Genetics

authors： Seale TW,Brett M,Baron AJ,Fincham JR

更新日期：1977-06-01 00:00:00

abstract：:The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp1 and Dp2, and only fish with d...

journal_title：Genetics

authors： Kajishima T

更新日期：1977-05-01 00:00:00

abstract：:The distribution of four X-linked mutants (G6PD, Deutan, Protan and Xg) among lowland and once highly malarial populations of Sardinia discloses a clear-cut example of linkage disequiligrium between two of them (G6PD and Protan). In the same populations the distribution of G6PD-deficiency versus colorblindness of the ...

journal_title：Genetics

authors： Filippi G,Rinaldi A,Palmarino R,Seravalli E,Siniscalco M

更新日期：1977-05-01 00:00:00

abstract：:A variety of Saccharomyces strains were examined for the presence of 2micro DNA and, if present, for the pattern of fragments produced by its digestion with site-specific (restriction) endonucleases. Two strains were found that did not contain detectable levels of 2micro DNA, and two strains contained 2micro DNA molec...

journal_title：Genetics

authors： Livingston DM

更新日期：1977-05-01 00:00:00

abstract：:We studied microgeographic and temporal genetic differentiation in natural populations of Drosophila persimilis with respect to chromosome inversion and enzyme polymorphisms. Both inversion frequencies and allozyme frequencies varied significantly over short distances. Neither differed significantly between morning an...

journal_title：Genetics

authors： Taylor CE,Powell JR

更新日期：1977-04-01 00:00:00

abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...

journal_title：Genetics

authors： Turner BC

更新日期：1977-03-01 00:00:00

abstract：:The genetic effects of one generation of spermatogonial X-irradiation in rats, by a single dose of 600r in one experiment and by a fractionated dose of 450r in another, were measured in three generations of their descendants. Estimates of dominant lethal mutation rates--(2 to 3) X 10-4/gamete/r--from litter size diffe...

journal_title：Genetics

authors： Chambers JR,Chapman AB

更新日期：1977-02-01 00:00:00

abstract：:Seventeen lines, each homozygous for a different X chromosome but all with a common autosomal genetic blackground, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character. --The regression coefficient of male mean on fema...

journal_title：Genetics

authors： Frankham R

更新日期：1977-01-01 00:00:00

abstract：:Acrylamide gel electrophoresis was performed on the enzyme xanthine dehydrogenase in sixty isochromosomal lines of Drosophila persimilis from three geographic populations. Sequential electrophoretic analysis using varied gel concentrations and buffers revealed twenty-three alleles in this species where only five had b...

journal_title：Genetics

authors： Coyne JA

更新日期：1976-11-01 00:00:00

abstract：:A female frog heterozygous at two unlinked loci, specifying electrophoretic forms of mannosephosphate isomerase (MPI) and malate dehydrogenase (MDH) was crossed to male frogs homozygous for different alleles at each locus. In the offspring approximately ten percent proved to be triploid according to nucleolar and chro...

journal_title：Genetics

authors： Wright DA,Huang CP,Chuoke BD

更新日期：1976-10-01 00:00:00

abstract：:Two large experiments were conducted in order to evaluate the heterozygous effects of irradiated chromosomes on viability. Mutations were accumulated on several hundred second chromosomes by delivering doses of 2,500r over either two or four generations for total X-ray exposures of 5,000r or 10,000r. Chromosomes treat...

journal_title：Genetics

authors： Simmons MJ

更新日期：1976-10-01 00:00:00

abstract：:Reciprocal recurrent selection (RRS), which assumes overdominant loci to be important, alters two genetically different populations to improve their crossbred mean. Individual plants from two populations (A and B) are selfed and also crossed with plants from the reciprocal female tester population (B and A, respective...

journal_title：Genetics

authors： Moreno-Gonzalez J,Grossman M

更新日期：1976-09-01 00:00:00

abstract：:The purpose of this study was to characterize two mutator stocks of yeast which were induced and selected on the basis of high spontaneous reversion rates of the suppressible "ochre" nonsense allele lys1-1. In the mutator stock VA-3, a single mutation, designated mut1-1, is responsible for the increase in the reversio...

journal_title：Genetics

authors： Gottlieb DJ,von Borstel RC

更新日期：1976-08-01 00:00:00

abstract：:The consequences of a discontinuity in the migration rate and of a geographical barrier in the habitat are studied in a diffusion model of migration and selection. The treatment is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is supposed further that...

journal_title：Genetics

authors： Nagylaki T

更新日期：1976-08-01 00:00:00

abstract：:Florida teosinte from Honduras and Guanajuato teosinte have most of their knobs internally located and a common inversion in the short arm of chromosome 8. Teosintes from northern Guatemala, Huixta and Monajil, have all their knobs terminally located and do not have any inversions. Therefore, Florida teosinte from Hon...

journal_title：Genetics

authors： Ting YC

更新日期：1976-08-01 00:00:00